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As of writing, the current pecl runkit-0.9 package does not compile with PHP 5.2+ . Below is how I got the latest installed from svn trunk on CentOS-5.4 with php-5.2.9.

• Install runkit:
  
        svn co http://svn.php.net/repository/pecl/runkit/trunk/
      cd trunk
      phpize
      ./configure
      make
      make install
• Create "/etc/php.d/runkit.ini":
  
        extension=runkit.so
• Restart apache and validate with phpinfo.

Note: you would need php-pear and php-devel installed already.