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In a recent interview with Wired, Nobel laureate Venkatraman Ramakrishnan discusses his book Why We Die, in which he argues that death is not genetically programmed but rather a consequence of evolution favoring reproduction over longevity. Here are some of the most thought-provoking excerpts: WIRED: Professor Ramakrishnan, the crucial question in your book is why we die. But exactly what is death? Venki Ramakrishnan: By death, we mean the irreversible loss of the ability to function as a coherent individual. It is the result of the failure of a critical system or apparatus, for example, heart, brain, lung, or kidney failure. In this sense there is an apparent paradox: When our organism, as a whole, is alive, millions of cells within us are constantly dying, and we do not even realize it. On the other hand, at the time of death, most of the cells in our bodies are still alive, and entire organs are still functioning and can be donated to people in need of transplantation. But at that point the body has lost the ability to function as a whole. In this sense, it is therefore important to distinguish between cell death and death of the individual. Speaking of death and aging, you say in your most recent book that you "wanted to offer an objective look at our current understanding of the two phenomena." What was the biggest surprise or most deeply held belief that you had to reconsider while writing and researching this work? There have been several surprises, actually. One is that death, contrary to what one might think, is not programmed by our genes. Evolution does not care how long we live, but merely selects the ability to pass on our genes, a process known as "fitness" in evolutionary biology. Thus, the traits that are selected are those that help us survive childhood and reproduce. And it is these traits, later in life, that cause aging and decline. Another curious finding was the fact that aging is not simply due to wear and tear on cells. Wear and tear happens constantly in all living things, yet different species have very different lifespans. Instead, lifespan is the result of a balance between the expenditure of resources needed to keep the organism functioning and repairing it and those needed to make it grow, mature, and keep it healthy until it reproduces and nurtures offspring. Do you think there is an aspect of the biology of aging that is still deeply misunderstood by the general public? Certainly the indefinite extension of life. Although in principle there are no laws or constraints that prevent us from living much longer than we do currently, great longevity or "eternal youth" are still far off, and very significant obstacles to increasing our maximum life expectancy remain. We must also beware of the pseudoscience -- and business -- around the concepts of "anti-aging" or the "reversal of aging." These are often baseless concepts, unsupported by hard evidence, even though they may use language that sounds scientific. Unfortunately, we are all afraid of growing old and dying, so we are very sensitive to any claim that promises to help us avoid it. [...] What do you think are the social and ethical implications of our desire to live longer? Ever since we became aware of our mortality, we have desired to defeat aging and death. However, our individual desires may conflict with what is best for society. A society in which fertility rates are very low and lifespans are very high will be a stagnant society, with very slow generational turnover, and probably much less dynamic and creative. The Nobel Prize-winning South American novelist Mario Vargas Llosa, who recently passed away, expressed it best: "Old age on the one hand terrifies us, but when we feel anxious, it is important to remember how terrible it would be to live forever. If eternity were guaranteed, all the incentives and illusions of life would vanish. This thought can help us live old age in a better way."

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Microsoft has acknowledged that Classic Outlook can mysteriously transform into a system resource hog, causing CPU usage spikes between 30-50% and significantly increasing power consumption on both Windows 10 and 11 systems. Users first reported the issue in November 2024, but Microsoft only confirmed the problem this week, offering little resolution beyond stating that "the Outlook Team is investigating this issue." The company's sole workaround involves forcing a switch to the Semi-Annual Channel update through registry edits -- an approach many enterprise environments will likely avoid. Microsoft hasn't announced a definitive end date for Classic Outlook, but the company continues pushing users toward its New Outlook client despite its incomplete feature set.

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After more than a decade of development, Harvard's insect-sized flying robot, RoboBee, has successfully learned to land using dragonfly-inspired legs and improved flight controls. The researchers see RoboBee as a potential substitute for endangered bees, assisting in the pollination of plants. From a report: RoboBee is a micro flying robot that Harvard has been developing since 2013. As the name suggests, it is the size of a bee, capable of flying like a bee and hovering in mid-air. Its wings are 3 cm long and it weighs only 0.08 g. The weight was reduced by using light piezoelectric elements instead of motors. Piezoelectric elements change shape when an electric current flows through them. The researchers were able to make RoboBee flap its wings 120 times per second by turning the current on and off, which is similar to actual insects. While RoboBee exhibited flight capabilities comparable to those of a bee, the real problem was landing. Being too light and having short wings, it could not withstand the air turbulence generated during landing. It is easy to understand if you think about the strong winds generated when a helicopter approaches the ground. Christian Chan, a graduate student at Harvard who participated in the research, said, "Until now, it was a matter of shutting off the robot while it attempted to land and praying for a proper touchdown." To ensure RoboBee's safe landing, it was important to dissipate energy just before touchdown. Hyun Nak-Seung, a professor at Purdue University who participated in the development of RoboBee, explained, "For any flying object, the success of landing depends on minimizing speed just before impact and rapidly dissipating energy afterward. Even for tiny flapping like RoboBee's, the ground effect cannot be ignored, and after landing, the risk of bouncing or rolling makes the situation more complex." The findings have been published in the journal Science Robotics.

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Researchers at the University of Tokyo have created what they believe is the largest single piece of lab-grown meat to date: a chicken nugget-sized chunk measuring 7 centimeters long, 4 centimeters wide, and 2.25 centimeters thick, weighing 11 grams. The breakthrough, reported today in Trends in Biotechnology, uses an artificial circulatory system to overcome a fundamental limitation in cultured meat production. The team, led by biohybrid system engineer Shoji Takeuchi, grew cells around a network of semipermeable hollow fibers -- similar to those used in water filters and dialysis machines -- that deliver nutrients and oxygen throughout the tissue. Unlike most commercial approaches that produce tiny meat fragments later assembled with binders or scaffolds, this method creates a single coherent piece with more natural structure and texture. This is the first working model using tubes to grow muscle tissue into a thick slab, according to Mark Post, chief science officer at Mosa Meat, who created the world's first lab-grown hamburger in 2013. Significant hurdles remain before commercialization. The hollow fibers aren't edible and must be manually removed. Researchers are exploring automating this process or creating edible alternatives using cellulose.

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Discord has begun testing age verification via facial scans or ID uploads for users in the UK and Australia seeking access to sensitive content. "The chat app's new process has been described as an 'experiment,' and comes in response to laws passed in those countries that place guardrails on youth access to online platforms," reports Gizmodo. From the report: Users may be asked to verify their age when encountering content that has been flagged by Discord's systems as being sensitive in nature, or when they change their settings to enable access to sensitive content. The app will ask users to scan their face through a computer or smartphone webcam; alternatively, they can scan a driver's license or other form of ID. "We're currently running tests in select regions to age-gate access to certain spaces or user settings," a spokesperson for Discord said in a statement. "The information shared to power the age verification method is only used for the one-time age verification process and is not stored by Discord or our vendor. For Face Scan, the solution our vendor uses operates on-device, which means there is no collection of any biometric information when you scan your face. For ID verification, the scan of your ID is deleted upon verification."

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An anonymous reader quotes a report from 404 Media: As part of the company's months-long obsession with catching employees leaking internal developments to the press, staff at Wordpress parent company Automattic recently noticed individually-unique watermarks on internal sites, according to employees who spoke to 404 Media. Automattic added the watermarks to an internal employee communications platform called P2. P2 is a WordPress product other workplaces can also use. There are hundreds of P2 sites across teams at Automattic alone; many are team-specific, but some are company-wide for announcements. The watermarks in Automattic's P2 instance are nearly invisible, rendered as a pattern overlaid on the site's white page backgrounds. Zooming in or manually changing the background color reveals the pattern. If, for example, a journalist published a screenshot leaked to them that was taken from P2, Automattic could theoretically identify the employee who shared it. In October, as part of a series of buyout offers meant to test employee's loyalty to his leadership, Automattic CEO Matt Mullenweg issued a threat for anyone speaking to the press, saying they should "exit gracefully, or be fired tomorrow with no severance." Earlier this month, the company laid off nearly 300 people. [...] It's not clear when the watermarks started appearing on P2, and Automattic has not responded to a request for comment. But Mullenweg has been warring with web hosting platform WP Engine -- and as the story has developed, seemingly with his own staff -- since last year. [...] One Automattic employee told me they don't think anyone is shocked by the watermarking, considering Mullenweg's ongoing campaign to find leakers, but that it's still adding to the uncertain, demoralized environment at the company. "Can't help but feel even more paranoid now," they said.

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For the first time -- and despite fears that it might never happen -- nations have agreed a series of measures to prevent, prepare for and respond to pandemics. Nature: The terms of the first global pandemic accord were still being hashed out at the World Health Organization (WHO) headquarters in Geneva, Switzerland, up until the early hours of 16 April. "This is a definitive moment in the history of global health," says Lawrence Gostin, a specialist in health law and policy at Georgetown University in Washington DC, who followed the negotiations closely. The accord "sets out some very important norms to keep the world safe," he says. The accord was agreed without the United States, which withdrew from the pandemic treaty the day that President Trump was inaugurated. This reduces its power, says Gostin, but is also a source of strength. "Instead of collapsing in the face of President Trump's assault on global health, the world came together." The treaty is not perfect but represents a major achievement, says Michelle Childs, policy advocacy director at the non-profit organization Drugs for Neglected Diseases Initiative in Geneva. "People didn't think that they'd get to this stage of agreeing at all."

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After over 40 years in operation, the last RadioShack store in Maryland is closing. Store manager Cindy Henning, who worked there for three decades, reflected on the joy of helping customers and the legacy left by late owner Michael King: Henning told WTOP she's going to miss it dearly. She's worked there for three decades. "We would have a lot of fun. That was half of our day was to have fun with people and show them how electronics work," Henning said. It was owned and operated by longtime local resident Michael King, who passed away at the end of January at the age of 79. His son Edward has taken over as owner. "It's the end of an era," he said. King said his grandfather owned a TV repair shop in the '50s and then his dad worked with him. They started carrying RadioShack products and grew to franchise three stores in Maryland. The RadioShack franchise first declared bankruptcy in 2015. King said they used the RadioShack name, but they don't have a warehouse in the U.S., so they were buying product from other wholesalers and selling it. "It was fun while it lasted, but it's not the same anymore," King said. "I know my dad realized that." The store's last day is Saturday, April 26.

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According to Bloomberg (paywalled), OpenAI is in talks to buy AI-assisted coding tool Windsurf for about $3 billion. "The deal would be OpenAI's largest to date, the terms of which have not yet been finalized," notes Reuters. From a report: Windsurf was in talks with investors such as Kleiner Perkins and General Catalyst to raise funding at a $3 billion valuation, the report added. It closed a $150 million funding round led by General Catalyst last year, valuing it at $1.25 billion.

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An anonymous reader quotes a report from TechCrunch: Google on Wednesday said it suspended 39.2 million advertiser accounts on its platform in 2024 -- more than triple the number from the previous year -- in its latest crackdown on ad fraud. By leveraging large language models (LLMs) and using signals such as business impersonation and illegitimate payment details, the search giant said it could suspend a "vast majority" of ad accounts before they ever served an ad. Last year, Google launched over 50 LLM enhancements to improve its safety enforcement mechanisms across all its platforms. "While these AI models are very, very important to us and have delivered a series of impressive improvements, we still have humans involved throughout the process," said Alex Rodriguez, a general manager for Ads Safety at Google, in a virtual media roundtable. The executive told reporters that a team of over 100 experts assembled across Google, including members from the Ads Safety team, the Trust and Safety division, and researchers from DeepMind. "In total, Google said it blocked 5.1 billion ads last year and removed 1.3 billion pages," adds TechCrunch. "In comparison, it blocked over 5.5 billion ads and took action against 2.1 billion publisher pages in 2023. The company also restricted 9.1 billion ads last year, it said."

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OpenAI has released Codex CLI, an open-source coding agent that runs locally in users' terminal software. Announced alongside the company's new o3 and o4-mini models, Codex CLI directly connects OpenAI's AI systems with local code and computing tasks, enabling them to write and manipulate code on users' machines. The lightweight tool allows developers to leverage multimodal reasoning capabilities by passing screenshots or sketches to the model while providing access to local code repositories. Unlike more ambitious future plans for an "agentic software engineer" that could potentially build entire applications from descriptions, Codex CLI focuses specifically on integrating AI models with command-line interfaces. To accelerate adoption, OpenAI is distributing $1 million in API credits through a grant program, offering $25,000 blocks to selected projects. While the tool expands AI's role in programming workflows, it comes with inherent risks -- studies show AI coding models frequently fail to fix security vulnerabilities and sometimes introduce new bugs, particularly concerning when given system-level access.

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OpenAI has released two new AI models that can "think with images" during their reasoning process. The o3 and o4-mini models represent a significant advancement in visual perception, enabling them to manipulate images -- cropping, zooming, and rotating -- as part of their analytical process. Unlike previous models, o3 and o4-mini can agentically use all of ChatGPT's tools, including web search, Python code execution, and image generation. This allows them to tackle multi-faceted problems by selecting appropriate tools based on the task at hand. The models have set new state-of-the-art performance benchmarks across multiple domains. On visual tasks, o3 achieved 86.8% accuracy on MathVista and 78.6% on CharXiv-Reasoning, while o4-mini scored 91.6% on AIME 2024 competitions. In expert evaluations, o3 made 20% fewer major errors than its predecessor on complex real-world tasks. ChatGPT Plus, Pro, and Team users will see o3, o4-mini, and o4-mini-high in the model selector starting today, replacing o1, o3â'mini, and o3â'miniâ'high.

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The Trump administration plans to eliminate the IRS' Direct File program, an electronic system for filing tax returns directly to the agency for free, AP reported Wednesday, citing two people familiar with the decision. From the report: The program developed during Joe Biden's presidency was credited by users with making tax filing easy, fast and economical. But Republican lawmakers and commercial tax preparation companies complained it was a waste of taxpayer money because free filing programs already exist, although they are hard to use.

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Google has announced that it will begin phasing out country code top-level domains (ccTLDs) such as google.ng and google.com.br, redirecting all traffic to google.com. The change comes after improvements in Google's localization capabilities rendered these separate domains unnecessary. Since 2017, Google has provided identical local search experiences whether users visited country-specific domains or google.com. The transition will roll out gradually over the coming months, and users may need to re-establish search preferences during the migration.

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About 18% of songs uploaded to Deezer are fully generated by AI, the French streaming platform said on Wednesday, underscoring the technology's growing use amid copyright risks and concerns about fair payouts to artists. From a report: Deezer said more than 20,000 AI-generated tracks are uploaded on its platform each day, which is nearly twice the number reported four months ago. "AI-generated content continues to flood streaming platforms like Deezer and we see no sign of it slowing down," said Aurelien Herault, the company's innovation chief.

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Enterprise software optimization is accelerating as companies face potential budget freezes in 2025, according to new research from UBS reviewed by Slashdot. Following discussions with two leading SaaSOps vendors, analysts report that 21% of organizations cut their SaaS spend last year, with a staggering 30% of existing licenses sitting unused. SaaS rationalization efforts are targeting familiar categories: collaboration tools (Zoom, Teams, Slack), project management solutions, and sales engagement platforms. Back-office systems like Workday remain relatively insulated due to their stickiness and pricing leverage, while front-office software faces mixed pressures. "Companies were looking to return to spend growth in 2HF25 from cost cutting but now that might no longer be the case," one CEO told UBS.

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CISA says the U.S. government has extended funding to ensure no continuity issues with the critical Common Vulnerabilities and Exposures (CVE) program. From a report: "The CVE Program is invaluable to cyber community and a priority of CISA," the U.S. cybersecurity agency told BleepingComputer. "Last night, CISA executed the option period on the contract to ensure there will be no lapse in critical CVE services. We appreciate our partners' and stakeholders' patience." The announcement follows a warning from MITRE Vice President Yosry Barsoum that government funding for the CVE and CWE programs was set to expire today, April 16, potentially leading to widespread disruption across the cybersecurity industry. "If a break in service were to occur, we anticipate multiple impacts to CVE, including deterioration of national vulnerability databases and advisories, tool vendors, incident response operations, and all manner of critical infrastructure," Barsoum said.

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More than half of the top privately held AI companies based in the U.S. have at least one immigrant founder, according to an analysis from the Institute for Progress. From the report: The IFP analysis of the top AI-related startups in the Forbes AI 2025 list found that 25 -- or 60% -- of the 42 companies based in the U.S. were founded or co-founded by immigrants. The founders of those companies "hail from 25 countries, with India leading (nine founders), followed by China (eight founders) and then France (three founders). Australia, the U.K., Canada, Israel, Romania, and Chile all have two founders each." Among them is OpenAI -- whose co-founders include Elon Musk, born in South Africa, and Ilya Sutskever, born in Russia -- and Databricks, whose co-founders were born in Iran, Romania and China. The analysis echoes previous findings about the key role foreign-born scientists and engineers have played in the U.S. tech industry and the broader economy.

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Figma has confidentially filed for an IPO with the SEC, marking a major move more than a year after scrapping its $20 billion acquisition deal with Adobe due to regulatory pushback. CNBC reports: Figma's software is popular among designers inside companies who need to collaborate on prototypes for websites and apps. The company was valued at $12.5 billion in a 2024 tender offer. "There are two paths that venture-funded startups go down," Dylan Field, Figma's co-founder and CEO, said in an interview with The Verge last year. "You either get acquired or you go public. And we explored thoroughly the acquisition route." The announcement lands at a precarious moment for the tech IPO market, which has been largely dormant since late 2021. The Trump presidency was expected to revive new offerings due to promises of less burdensome regulations.

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The CVE and CWE programs are at risk of shutdown as MITRE's DHS contract expires on April 16, 2025, with no confirmed renewal. Without continued funding, the ability to standardize, track, and respond to software vulnerabilities could collapse, leaving the cybersecurity community scrambling in a fragmented and dangerously opaque environment. Forbes reports: "Failure to renew MITRE's contract for the CVE program, seemingly set to expire on April 16, 2025, risks significant disruption," said Jason Soroko, Senior Fellow at Sectigo. "A service break would likely degrade national vulnerability databases and advisories. This lapse could negatively affect tool vendors, incident response operations, and critical infrastructure broadly. MITRE emphasizes its continued commitment but warns of these potential impacts if the contracting pathway is not maintained." MITRE has indicated that historical CVE records will remain accessible via GitHub, but without continued funding, the operational side of the program -- including assignment of new CVEs -- will effectively go dark. That's not a minor inconvenience. It could upend how the global cybersecurity community identifies, communicates, and responds to new threats. [...] MITRE has said that discussions with the U.S. government are active and that it remains committed to the CVE mission. But with the expiration date looming, time is running short -- and the consequences of even a temporary gap are severe.

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